Dr. Daniel Pierce (Eric McCormack), an eccentric neuropsychiatrist and Davenport Award–winning neuroscience professor at Chicago Lake Michigan University (CLMU). Pierce is a paranoid schizophrenic.
Pierce doesn’t have the best social skills, but he is a clever fellow and uses what he has, including his hallucinations, which sometimes enable him to pick out subtle clues to solve a problem.
In his spare time, Pierce solves crimes for the Chicago Branch of the Federal Bureau of Investigations with Special Agent Katherine Rose “Kate” Moretti, (Rachel Leigh Cook), a former student who recruited Daniel for the FBI.
Also on the team is Max Lewicki (Arjay Smith), Dr. Pierce’s teaching assistant who lives with Daniel and helps him sort out what is real and what is a manifestation of his mind. Oh, and let’s not forget Natalie Vincent (Kelly Rowan). She is Pierce’s best friend, advisor and former romantic partner who happens to be one of the doctor’s hallucinations.
Another of Daniel’s hallucinations is his late mother Margaret Pierce (JoBeth Williams), who died from cancer 25 years earlier. Daniel’s wealthy father, James Alan Pierce (Peter Coyote) is still alive but has Alzheimer’s disease.
When Daniel’s team needs to mull over a problem or just relax, they hangout at a local bar owned by Joe Moretti (Dan Lauria) a retired CPD homicide detective who happens to be Kate’s widowed father.
Eventually, Daniel tires of all the administrative hassles at CLMU and moves to Paris.
Black Box/ABC/2014 (Bipolar)
Catherine Black (Kelly Riley), a world-famous neuroscientist known as “the Marco Polo of the brain” who works at the Neuroscience Research and Treatment Center aka “The Cube.”
The institution attracts patients from all over the world with rare and often hallucinogenic conditions, like alien-hand syndrome, Capgras delusion, Jerusalem syndrome, narcolepsy, exploding head syndrome and schizophrenia.
Despite her success, Dr. Black has a secret. She has a bipolar disorder and is subject to abrupt, extreme mood swings from manic to depressive. Her psychiatrist Dr. Helen Hartramph (Vanessa Redgrave) is the only one who knows her secret. Catherine’s mother also suffered from a bipolar disorder. She committed suicide by drowning herself in the ocean.
Catherine frequently refuses to take her medication because she fears becoming dull or, worse, “normal,” which leads her to sleep around, perch on hotel balcony railings while drunk and dance to music that only she can hear. Her chef boyfriend, Will Van Renseller (David Ajala) prefers Catherine’s personality when she is off her medication.
Eventually, after Catherine experiences hallucinations, her colleagues learn of her bipolar disorder. Her boss lets her keep her job, on the condition he monitors her progress.
Agents of S.H.I.E.L.D/ABC/2013+ (Aphasia)
Leopold “Leo” Fitz (Iain De Caestecker), member of the Science Tech division of S.H.I.E.L.D., a Homeland Security agency designed to battle terrorism and the sinister agents of HYDRA. Injured in the line of duty, Leo suffered from Aphasia, caused by a lack of oxygen to his brain.
Born in Scotland on Wednesday, August 19, 1987, agent Fisk is a genius engineer/scientist who attended the S.H.I.E.L.D. Academy of Science and Technology in 2004 with bio-chem expert Jemma Simmons (Elizabeth Henstridge) who became his best friend and partner when they were hired to work for S.H.I.E.L.D.’s Sci-Tech division. They were recruited to Agent Coulson’s team and worked with them on all of their missions.
During the “HYDRA Uprising,” Fitz and other S.H.I.E.L.D. agents searched for clairvoyant John Garret, the head of the Centipede Project. During the mission, Leo learned that his fellow S.H.I.E.L.D. agent Grant Ward (Brett Dalton) was actually a sleeper agent for HYDRA.
When Ward found Fitz and Simmons hiding in a medical pod, instead of killing them (per his order from Garrett), he gave them a chance to live by jettisoning the pod which sank to the ocean floor. Fortunately, they escaped to the surface, (there was only one oxygen mask, and Fitz gave it to Simmons) but Fitz spent a long period of time without oxygen which damaged his brain. Consequently, he fell into a coma.
When he awoke, Leo showed signs of aphasia, a language disorder that makes it difficult to communicate/remembering specific words or names. He now had a lowered speech rate and stumbled with words, especially when he gets agitated. He uses simple phrases rather than the long words he used to use. He also leaves his sentences hanging as he moves on to his next thought.
During his recovery, Leo exhibited signs of amnesia, personality regression, memory loss and hallucinations. As for his hallucinations, Leo talked to Jemma Simmons, his (no longer present) lab partner, for whom he held a strong romantic interest.
Fitz also lost the ability to understand metaphors, allegories and simple day-to-day phrases. For example when he hears someone say, “Guys, drop everything” he replies, “No, this is worth a fortune. I’m not going to drop it.” Another time, when he hears a comment about an impending dire situation (“Storm’s coming.”) Fitz responds, “No, weather’s fine, actually. There’s not a cloud in the sky, I checked.”
“Simmons is not real. I….I knew that. But I needed her, and she….she left. And everybody treats me like…like….like I’m broken. Like I can’t help…But I’m still….smart! I am! It’s just…hard, sometimes. And now Simmons is back, really back, and she’s trying to be nice and treat me the…the….the same. But I know I’ve changed. I know I’m….different. And I can’t go back. I have new friends now. Mack….Mack helps me get the words right. He is patient and…and…and tells me I’m doing a good job. He understands.” – Leo Fisk
Fisk had a long road to recovery, but he slowly began to regain much of what he lost before his accident. He also learned that his friend, Jemma Simmons was alive and they soon became a couple.
(Dorian Harewood) Julian Wilkes, a brilliant black scientist confined to a wheelchair who designed Viper, a high-tech, supercharged pursuit vehicle built to fight crime in the world of the near future.
Disabled auto wizard Julian Wilkes (Dorian Harewood) modified a Dodge Viper sports car roadster for the pursuit and capture of criminals too slippery for ordinary police patrol car chases.
The Viper was equipped with computers; armor plating; morphing circuitry that changed the car’s color and shape; side mounted firearms that launched rockets, grappling hooks and netting; and a flying spy camera.
To drive this dynamo of a car, Wilkes memory wiped the mind of Mob driver Michael Payton and gave him the alternate personality of Joe Astor (James McCaffrey).
A fast-talking scam artist Frankie Waters (Joe Nipote) who worked for the police motor pool provided Wilkes and Astor with inside information.
Dr. Miles Hawkins (Carl Lumbly), a black scientist and owner of Hawkins Technologies who was shot by a crooked cop and left paralyzed from the waist down during the L.A. Riots of the 1990s.
Developing an exoskeleton suit that gave him the ability to walk, Miles Hawkins fought corruption from his secret headquarters beneath his coastal home near Port Columbia.
Hawkins originally developed his exo-skeleton with the help of his associate John Stonebrake (Roger Rees).
When Miles discovered the suit’s superhuman strength and speed, he decided to fight crime as a vigilante known as M.A.N.T.I.S. To stop criminals, M.A.N.T.I.S fires special darts that impart a temporary paralytic shock.
Miles fought corruption from his secret headquarters beneath his coastal home near Port Columbia. Dr. Hawkins placed the following newspaper ad “Need Help? No One To Turn To? 1-500-4-MANTIS.”
He traveled via a flying car known as the Chrysalis, originally designed as a prototype for the police. Miles’ alter ego was eventually discovered by a police detective Lt. Leora Maxwell (Gaylyn Gorg) but instead of exposing Miles, she joined forces with M.A.N.T.I.S to battle crime and bring back justice to the streets.
A bicycle courier named Taylor Savidge (Christopher Russell Gartin) – who also knew about M.A.N.T.I.S. – did the legwork for Miles Hawkins.
M.A.N.T.I.S. stood for Mechanically Automated Neuro Transmitter Interactive System.