Dr. Daniel Pierce (Eric McCormack), an eccentric neuropsychiatrist and Davenport Award–winning neuroscience professor at Chicago Lake Michigan University (CLMU). Pierce is a paranoid schizophrenic.
Pierce doesn’t have the best social skills, but he is a clever fellow and uses what he has, including his hallucinations, which sometimes enable him to pick out subtle clues to solve a problem.
In his spare time, Pierce solves crimes for the Chicago Branch of the Federal Bureau of Investigations with Special Agent Katherine Rose “Kate” Moretti, (Rachel Leigh Cook), a former student who recruited Daniel for the FBI.
Also on the team is Max Lewicki (Arjay Smith), Dr. Pierce’s teaching assistant who lives with Daniel and helps him sort out what is real and what is a manifestation of his mind. Oh, and let’s not forget Natalie Vincent (Kelly Rowan). She is Pierce’s best friend, advisor and former romantic partner who happens to be one of the doctor’s hallucinations.
Another of Daniel’s hallucinations is his late mother Margaret Pierce (JoBeth Williams), who died from cancer 25 years earlier. Daniel’s wealthy father, James Alan Pierce (Peter Coyote) is still alive but has Alzheimer’s disease.
When Daniel’s team needs to mull over a problem or just relax, they hangout at a local bar owned by Joe Moretti (Dan Lauria) a retired CPD homicide detective who happens to be Kate’s widowed father.
Eventually, Daniel tires of all the administrative hassles at CLMU and moves to Paris.